F. Research/Project Reports
http://localhost:8080/xmlui/handle/123456789/2292
2024-03-28T16:18:07ZRegulation of Mitochondrial Bioenergetics and Apoptosis Induction In T Cell Lymphomas
http://localhost:8080/xmlui/handle/123456789/2345
Regulation of Mitochondrial Bioenergetics and Apoptosis Induction In T Cell Lymphomas
Mukherjee, Piyali
Tumor cells have evolved strategies to down regulate proteins primarily involved in the induction of apoptosis. Since mitochondria play a key role in the regulation of apoptosis identification of novel mitochondrial proteins that programs the tumor cells to endorse the apoptotic pathway is urgently required to develop new anti-cancer therapies and better prognosis of more aggressive forms of cancer like T cell lymphomas. SARM holds such a promise and a detailed mechanistic insight of SARM regulation at the mitochondria is the major goal of this study. How this single-molecule SARM regulates the mitochondrial proteome that leads to excess ROS generation? How SARM regulates mitochondrial bioenergetics that skews the cells to the apoptotic pathway and how this regulation is deranged in cancer. The goal of this proposal is to robustly investigate this novel regulation of mitochondrial energy metabolism by SARM and how this pathway is altered in cancer with emphasis on T cell lymphomas.
The primary objectives of this project were:
Aim1: To examine the role of SARM in cellular apoptosis in nasal NK/T cell lymphoma (NNKTL)
Aim2: To understand the regulation of mitochondrial bioenergetics by SARM leading to cellular apoptosis in NNKTL
Aim3: To identify SARM interacting partners at the mitochondria in NNKTL
n T Cell Lymphomas
Dynamics of stock market cycles: a systematic Introspection from some recent evidences
http://localhost:8080/xmlui/handle/123456789/2344
Dynamics of stock market cycles: a systematic Introspection from some recent evidences
Chakrabarti, Gagari
Historically, stock-market cycles, crashes and the resultant panic have ended in ultimate devastating impact on the rest of the economy. Proper macroeconomic management and accomplishing macroeconomic objectives require both in terms of depth and width, sound health of the financial system. A fragile financial sector is often identified as the prime factor in generating and aggravating crises. Moreover, with extensive trade and financial integration, crises in one market immediately affect others through dynamic linkages among markets or “contagion”. Hence, at this juncture, inquiry into market dynamics becomes crucial. Present study intervenes here focusing on the two past significant stock-market crises namely, the dotcom bubble and the global melt-down of 2007-08. Around the five sub-phases the study found significant volatility transmission channels primarily through past-volatility impacts. In recent era of fluctuation and instability, the stock-markets have become more integrated where innovation and volatility impacts are strong and significantly positive. The news-impacts, however, are always less intense than past-volatility impacts. Moreover, even with increasing financial integration, there remains a basis for global portfolio diversification
Graphene Oxide based polyvalent metal oxide nanocomposite: preparation, characterization and efficiency evaluation on arsenic and fluoride removal from contaminated water
http://localhost:8080/xmlui/handle/123456789/2339
Graphene Oxide based polyvalent metal oxide nanocomposite: preparation, characterization and efficiency evaluation on arsenic and fluoride removal from contaminated water
Ghosh, Uday Chand; Palani, Sasi Kumar
Iron-Aluminum mixed oxide (HIAMO) and various proportions of Graphene oxide (GO)-incorporated iron-aluminium mixed oxide (GIAMO-1 to GIAMO-6) composite materials were prepared and characterized by several modern instrumental techniques such as FTIR, XRD, TGA/DTA, SEM, TEM, and Raman spectroscopy. The prepared materials particularly GIAMO-1 and GIAMO-3 were employed for adsorption of the arsenic and fluoride from aqueous solutions respectively.
GIAMO-1 shows very good (92–95%) arsenic(III) removal efficiency from water, which is 30–35% higher than pristine iron-aluminium oxide (HIAMO) from an aqueous solution (5.0 mg AsIII•L−1) at pH 7.0 (± 0.2) and 303 K.The kinetic data agree more closely with pseudo-first order equation (R2 = 0.98–0.99) than pseudo-second order equation (R2 = 0.92–0.93). The equilibrium data describe the Langmuir isotherm (R2 = 0.97–0.98) better than the Freundlich isotherm (R2 = 0.91–0.92), showing the Langmuir monolayer capacity 42.2836 mg•g−1 at 293 K which drops to 24.9170 mg•g−1 at 313 K.
Similarly, GIAMO-3 showed highest fluoride adsorption capacity (qe, mg g−1) at pH ∼ 7.0 and ambient temperature. The material showed an increase of qe with pH up to ∼5.5, and then reduced. Kinetically, fluoride adsorption took place obeying the pseudo-second order model. The Langmuir adsorption isotherm described the equilibrium data best with monolayer adsorption capacities 22.13, 22.90 and 27.75 mg g−1 at 288, 308 and 318 K, respectively, indicating endothermic nature of adsorption process, which was also confirmed from the thermodynamic analysis of equilibrium data. Fluoride adsorption efficiency of HIAGO had been predicted by modelling a single stage batch adsorber design parameters.
Protrusions; the role of actin cytoskeleton
http://localhost:8080/xmlui/handle/123456789/2302
Protrusions; the role of actin cytoskeleton
Majumder, Pralay
Singed (human Fascin), being an parallel bundle actin cross linker, is required for cell motility in both Droso¬phila and mammalian systems, as Fascin 1–dependent actin bundles are required for the formation of filopodia and invadopodia. Actin polymerization is the process through which the protrusions are formed but the stabilization of the protrusions are, perhaps, determined by the stability of the parallel bundles. Performing different experiments in this project we have come to know about the potential role of different actin cross linker proteins in the cell migration during protrusion formation. Various data from this project also clarify the role of hyper expressed singed in the border cell migration. We have to some extent found the redundant protein of singed which is the vinculin protein as the double knock down result of both singed and vinculin gene affects the border cell migration almost two folds greater than that of their individual knock down effect.
2019-04-29T00:00:00Z