Synthesis and Characterization of Metal Organic Framework Based on 3d and 4f Metals

Abstract

This thesis covers the broader section of the chemistry and the material sciences of our daily needs. The main objective of our work was to design different 3d and 3d-4f hetero bimetallic Metal Organic Framework (MOF) using different clickable Schiff base ligand having N,N,O donor sites. We have further used co-ligand such as azide, thiocyanate, 4-tert-butyl-benzoic acid to increase the nuclearity of the metal complex. Careful design of these complexes has allowed us to isolate these complexes with versatile structural motif and application in the field of data storage, luminescence and sensing. We have explored the sensing study for the detection of the hazardous analytes such as sulfide (S2-) and Ag+ , Cu2+, Fe3+ by Metal Organic Framework. We have also studied the anti-cancer activity towards the breast cancer cells Zn azido and Zn perchloato complex where we have found that a 0.5 mM dose of the Zn-azido and Zn-perchlorato complex could kill the 81% and 72% of the breast cancer cells respectively. However Zn-azido complex affects the normal cell as well although Zn-perchlorato complex does not affect the normal cells. Hence Znperchlorato complex has potential biological activity and may be used for the therapeutic purposes. We have also synthesised 3d-4f metal complexes which could be used as fluorescence biomarker and could be used as data storage. This thesis covers a broader sector of material science in corroboration of biological studies in few cases.